Xiaoqun Wang

王 晓 群

Ruijin Hospital, Shanghai Jiao-Tong Univeristy School of Medicine

wangxq@shsmu.edu.cn

Research Goal

The long-term goal of Dr. Wang’s laboratory is to elucidate mechanisms underlying the pathogenesis of cardiometabolic-based chronic disease (CMBCD), and to optimize current diagnosis, risk stratification strategies, and treatment modalities of CMBCD.

Adipo-vascular axis in CMBCD

We focus on the casual relationship between adipose tissue and the pathogenesis of cardiovascular disease through multimodality imaging analysis, tissue proteomics, and basic research studies. We have identified a novel adipocytokine superfamily, C1q/TNF-related proteins (CTRPs), and demonstrated its critical role in atherogenesis through the adipo-vascular axis (Eur Heart J, 2016; Atherosclerosis 2016). We have been analyzing the synergistic and antagonistic effects of different CTRP members in regulating vascular injury and homeostasis, as well as their specific receptors.

Optimized management of CMBCD

We have established a large cohort (CAMPUS) comprised of patients with cardiometabolic disorders to optimize diagnostic and treatment strategy, and their clinical outcomes. We showed hyperglycemia and glycemic variability were strong predictors of adverse left ventricular remodeling and compromised myocardial functional recovery in patients with type 2 diabetes (Cardiovasc Diabetol, 2019, 2020; Int J Cardiol, 2022). On the other hand, we demonstrated that insulin resistance was a fundamental risk factor for impaired development of HFimpEF in non-diabetic patients (J Am Heart Assoc, 2022). We have been identifying novel metabolites and developing precise and high-throughput assays to aid in early risk stratification and intervention.

AI-based risk prediction of CMBCD

We are now developing AI-based algorithms to predict risk of coronary events from CTA data by integrating vulnerable plaque characteristics, CT-fractional flow reserve, and wall shear stress. This new AI-based model will profoundly improve the efficiency and accuracy of coronary risk prediction in a non-invasive way, especially in patients with only mild coronary artery stenosis. We are also characterizing myocardial and epicardial adipose tissue features, as well as strains to predicting myocardial remodeling and functional recovery.

Publications

  1. Wang, XQ, Nigro P, World C, Fujiwara K, Yan C, Berk BC. Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing kruppel-like factor 2. Circulation Research, 2012, 110(4): 560-568.
  2. Lu, L, Zhang RY, Wang XQ, Liu ZH, Shen Y, Ding FH, Meng H, Wang LJ, Yan XX, Yang K, Wang HB, Pu LJ, Zhang Q, Chen QJ, De Caterina R, Shen WF. C1q/TNF-related protein-1: an adipokine marking and promoting atherosclerosis. Eur. Heart J, 2016, 37(22): 1762-1771.
  3. Shen Y, Aihemaiti M, Shu XY, Yang CD, Chen JW, Dai Y, Ding FH, Yang ZK, Hu J, Zhang RY, Lu L, Wang XQ, Shen WF. Circulating Chromogranin B Is Associated With Left Ventricular Functional Recovery After Successful Recanalization of Chronic Total Occlusion. Front Cardiovasc Med, 2021, 8:756594.
  4. Yang CD, Shen Y, Lu L, Yang ZK, Hu J, Zhang RY, Shen WF, Ding FH, Wang XQ. Visit-to-visit HbA(1c) variability is associated with in-stent restenosis in patients with type 2 diabetes after percutaneous coronary intervention. Cardiovasc Diabetol; 2020, 19:133.
  5. Yang CD, Shen Y, Ding FH, Yang ZK, Hu J, Shen WF, Zhang RY, Lu L, Wang XQ. Visit-to-visit fasting plasma glucose variability is associated with left ventricular adverse remodeling in diabetic patients with STEMI. Cardiovasc Diabetol, 2020, 19:131.
  6. Yang CD, Pan WQ, Feng S, Quan JW, Chen JW, Shu XY, Aihemaiti M, Ding FH, Shen WF, Lu L, Zhang RY, Wang XQ. Insulin Resistance Is Associated with Heart Failure with Recovered Ejection Fraction in Patients without Diabetes. J Am Heart Assoc, 2022, 11:e026184.
  7. Yang CD, Aihemaiti M, Quan JW, Chen JW, Shu XY, Ding FH, Shen WF, Lu L, Zhang RY, Pan WQ, Wang XQ. HbA1c level is associated with the development of heart failure with recovered ejection fraction in hospitalized heart failure patients with type 2 diabetes. Int J Cardiol, 2023, 371:259-265.
  8. Feng S, Chen JW, Shu XY, Aihemaiti M, Quan JW, Lu L, Zhang RY, Yang CD, Wang XQ. Endothelial microparticles: A mechanosensitive regulator of vascular homeostasis and injury under shear stress. Front Cell Dev Biol, 2022, 10:980112.
  9. Shen Y, Aihemaiti M, Shu XY, Yang CD, Chen JW, Dai Y, Ding FH, Yang ZK, Hu J, Zhang RY, Lu L, Wang XQ, Shen WF. Circulating Chromogranin B Is Associated with Left Ventricular Functional Recovery After Successful Recanalization of Chronic Total Occlusion. Front Cardiovasc Med, 2021, 8:756594.
  10. Yang CD, Chen JW, Quan JW, Shu XY, Feng S, Aihemaiti M, Ding FH, Shen WF, Lu L, Zhang RY, Wang XQ. Long-term glycemic variability predicts compromised development of heart failure with improved ejection fraction: a cohort study. Frontiers in endocrinology, 2023, 14:1211954.
  11. Yang CD, Shen Y, Lu L, Ding FH, Yang ZK, Zhang RY, Shen WF, Jin W, Wang XQ. Insulin resistance and dysglycemia are associated with left ventricular remodeling after myocardial infarction in non-diabetic patients. Cardiovasc Diabetol, 2019, 18(1):100.
  12. Li, C, Chen J W, Ding F H, Shen Y, Liu Z H, Wang F, Zhang R Y, Shen W F, Lu L, Wang X Q. Relationship of High-Density Lipoprotein-Associated Arylesterase Activity to Systolic Heart Failure in Patients with and without Type 2 Diabetes. Sci Rep, 2019.
  13. Chen, Y, Wang X, Yang C, Su X, Yang W, Dai Y, Han H, Jiang J, Lu L, Wang H, Chen Q, Jin W. Decreased circulating catestatin levels are associated with coronary artery disease: The emerging anti-inflammatory role. Atherosclerosis, 2019, 281: 78-88.
  14. Chen, JW, Li C, Liu ZH, Shen Y, Ding FH, Shu XY, Zhang RY, Shen WF, Lu L, Wang XQ. The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Prediction of Carotid Intima-Media Thickness in Patients With Type 2 Diabetes. Front Endocrinol (Lausanne), 2019, 10(191).
  15. Li, C, Chen JW, Liu ZH, Shen Y, Ding FH, Gu G, Liu J, Qiu JP, Gao J, Zhang RY, Shen WF, Wang XQ, Lu L. CTRP5 promotes transcytosis and oxidative modification of low-density lipoprotein and the development of atherosclerosis. Atherosclerosis, 2018, 278: 197-209.
  16. Wang, F, Li C, Ding FH, Shen Y, Gao J, Liu ZH, Chen JW, Zhang RY, Shen WF, Wang XQ, Lu L. Increased serum TREM-1 level is associated with in-stent restenosis, and activation of TREM-1 promotes inflammation, proliferation and migration in vascular smooth muscle cells. Atherosclerosis, 2017, 267: 10-18.
  17. Liu, ZH, Li C, Chen JW, Shen Y, Gao J, Shen WF, Zhang RY, Wang XQ, Lu L. C1q/TNF-related protein 1 promotes endothelial barrier dysfunction under disturbed flow. Biochem Biophys Res Commun, 2017, 490(2): 580-586.
  18. Li, Y, Ren M, Wang X, Cui X, Zhao H, Zhao C, Zhou J, Guo Y, Hu Y, Yan C, Berk B, Wang J. Glutaredoxin 1 mediates the protective effect of steady laminar flow on endothelial cells against oxidative stress-induced apoptosis via inhibiting Bim. Sci Rep, 2017, 7(1): 15539.
  19. Wang, XQ, Liu ZH, Xue L, Lu L, Gao J, Shen Y, Yang K, Chen QJ, Zhang RY, Shen WF. C1q/TNF-related protein 1 links macrophage lipid metabolism to inflammation and atherosclerosis. Atherosclerosis, 2016, 250: 38-45.
  20. Yang, K, Wang X, Liu Z, Lu L, Mao J, Meng H, Wang Y, Hu Y, Zeng Y, Zhang X, Chen Q, Liu Y, Shen W. Oxidized low-density lipoprotein promotes macrophage lipid accumulation via the toll-like receptor 4-Src pathway. Circ J, 2015, 79(11): 2509-2516.
  21. Yang, K, He YS, Wang XQ, Lu L, Chen Q J, Liu J, Sun Z, Shen WF. MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4. FEBS Letters, 2011, 585(6): 854-860.
  22. Wang, XQ, Yang K, He Y S, Lu L, Shen WF. Receptor mediated elevation in FABP4 levels by advanced glycation end products induces cholesterol and triacylglycerol accumulation in THP-1 macrophages. Lipids, 2011, 46(6): 479-486.
  23. Yang, K, Wang XQ, He YS, Lu L, Chen QJ, Liu J, Shen WF. Advanced glycation end products induce chemokine/cytokine production via activation of p38 pathway and inhibit proliferation and migration of bone marrow mesenchymal stem cells. Cardiovasc Diabetol, 2010, 9: 66.

Awards

  1. Working Group Award, ESC WG on Atherosclerosis and Vascular Biology, 2023
  2. ESC Congress Award, European Society of Cardiology, 2023
  3. Paul Dudley Award, American Heart Associaiton, 2019
  4. Science and Technology Progress Award, the Second Prize, Ministry of Education, 2018
  5. Science and Technology Progress Award, the Second Prize, Shanghai Municipal Government, 2017
  6. Shanghai Rising Star Program, Shanghai Science and Technology Committee, 2016